abstract |
Disclosed is an anti-CD137 antigen-binding molecule having low side effects and having low side effects on non-tumor tissues such as normal tissues, while having an activating action, an cytotoxic activity, or an anti-tumor activity of immune cells, and a method of using them. It aims to provide. By discovering and preparing a CD137 antigen-binding molecule whose binding activity to CD137 changes depending on various substances in the target tissue (for example, a low-molecular compound), the activation action of immune cells, cytotoxic activity, Or, while having anti-tumor activity, it has a low action on non-tumor tissue such as normal tissue, provides an anti-CD137 antigen-binding molecule with few side effects, and provides a method of use, pharmaceutical preparation, and the like. The present disclosure also provides antigen-binding molecules whose antigen-binding activity varies depending on the low-molecular compound, a method for producing the same, and use thereof. |