| abstract |
The present invention: Novel dihydropyridine derivatives of formula (I) as modulators of nuclear receptors selected from androgen receptors and glucocorticoid receptors, methods for their preparation, pharmaceutical compositions comprising these compounds and them for cancer, metastatic cancer, benign prostatic hyperplasia, polycystic ovary syndrome ( PCOS), androgen receptors selected from alopecia, hirsutism, acne, hypogonadism, muscle loss disease, cachexia, Cushing's syndrome, weight gain caused by antipsychotic drugs, obesity, post-traumatic stress disorder and alcoholism, and/or Or to use in the manufacture of a therapeutic agent for a pathological condition or disease that can be improved by modulation of the glucocorticoid receptor. |