abstract |
The present disclosure is useful as a T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitor or as a dual inhibitor of the TIM-3 signaling pathway and the cell death 1 (PD-1) signaling pathway. -Relates to substituted 1,2,4-oxadiazole compounds and derivatives thereof. The present disclosure also relates to treating disorders by inhibiting immunosuppressive signals induced by TIM-3, PD-1, PD-L1 and/or PD-L2. |