| abstract |
The present invention provides CTLA-4 monoclonal antibodies, particularly humanized monoclonal antibodies that specifically bind CTLA-4 with high affinity. The invention also provides functional monoclonal antibodies that are cross-reactive to CTLA-4 in humans, cynomolgus monkeys, and mice. The present invention further provides amino acid sequences, cloning or expression vectors, host cells of the antibodies of the invention, and methods of expression or isolation of the antibodies. The epitope of the antibody is identified. Also provided are therapeutic compositions comprising the antibodies of the invention. The invention also provides methods of treating cancer and other diseases with anti-CTLA-4 antibodies. |