| abstract |
The present invention is (10R) -7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4- (metheno) pyra It relates to the crystalline form (form 24) of the zolo [4,3-h] [2,5,11] benzoxadiazacyclo-tetradecine-3-carbonitrile (loratinib) free base hydrate. The present invention also relates to pharmaceutical compositions comprising Form 24, and methods of using Form 24 and such compositions in the treatment of abnormal cell growth in mammals, such as cancer. |