| abstract |
The present invention relates to a composition for stem cell suppression of stem cells containing a substance that phosphorylates OCT4, wherein the substance that phosphorylates OCT4 according to the present invention is by phosphorylating 281st serine of mouse OCT4 or 288th serine of human OCT4 It is possible to effectively reduce the stem cell properties of various stem cells. Therefore, it can be effectively used for suppressing the proliferation of cancer, suppressing recurrence of cancer, suppressing metastasis of cancer, and suppressing the occurrence of anticancer drug resistance of cancer, and can also reduce stem cellity in normal stem cells, so as specific cells of embryonic stem cells. In the differentiation of, it is expected that the time can be shortened and the efficiency can be increased. |