| abstract |
The present invention relates to allogeneic-mesenchymal stem cells and uses thereof, comprising the step of treating interferon gamma and proteasome inhibitors to mesenchymal stem cells, suppressing transplant immunogenicity, improving immunomodulatory activity, It can suppress the activity of innate and adaptive immune cells, and even when exposed to inflammatory factors, it does not degenerate into inflammation-promoting cells, so it can stably maintain its immune suppression ability, and various inflammatory diseases (e.g., autoimmune diseases, graft-versus-host diseases, etc.) The present invention, which can produce mesenchymal stem cells capable of preventing or treating), relates to allogeneic-mesenchymal stem cells and uses thereof. |