| abstract |
The present invention relates to a method for producing X-ray contrast agent iomeprole, more specifically 5- (2-hydroxyacetamido) -N, N'-bis (2, 3-dihydroxypropyl) -2 , 4, 6-triiodoisophthalamide (1b) by adding an inorganic base, an inorganic chloride, a solvent, etc., and performing an N-methylation reaction, ion exchange the inorganic salt produced during the reaction while reducing the existing production time The present invention relates to a method of manufacturing iomeprole which can be easily separated and removed without resin treatment and minimizes reaction impurities. |