| abstract |
Anti-human 4-1BB antibodies and fragments thereof having one or more structural features not found in the reference anti-human 4-1BB antibody are provided, wherein the features can improve certain characteristics of the antibody as compared to the reference antibody. Various in vitro and in vivo methods and reagents related to the anti-human 4-1BB antibodies described herein are also provided. The methods include, for example, inducing T-cell proliferation using an anti-human 4-1BB antibody or fragment thereof, inducing T cell secretion of IFNγ, as well as detecting, preventing and / or curing cancer Enemies are treated. |