| abstract |
The present invention provides a recombinant adeno-associated virus (AAV) virion having a modified capsid protein, wherein the recombinant AAV (rAAV) virion has the ability to pass the barrier between larger intravitreal fluid and retinal cells, and As compared to the wild type AAV according to the larger retinal cell infectivity, rAAV virions include heterologous nucleic acid. The present invention provides a method of delivering a gene product to retinal cells of an individual. |