| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fb0b2ec1c62686bd1f63f161596afee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ffd5528fd07384d7b07ab484ed5b143 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-912
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2458-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57423
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-4833 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate |
2018-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6a9184d872e1f370c9f4d78cf78b70b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30a42451dd6448163037c2c925a1266c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa59404a5292c18d6fc174cef388d14b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1734852aea471a393fd448722fb3e27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeaf79bde0ced7a8b90e128bffba20f8 |
| publicationDate |
2020-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20200016242-A |
| titleOfInvention |
Prediction of Cancer Treatment Results by T-DM1 |
| abstract |
Improved methods of treating lung cancer are provided. Tumor samples of patients are analyzed by (i) DNA sequencing to detect the presence of HER2 mutations and (ii) mass spectrometric proteomic analysis to determine whether HER2 protein is expressed in tumor cells. The patient responds to treatment with trastuzumab emtansine (T-DM1) or an equivalent antibody-drug conjugate when a particular HER2 protein fragment is detected in patient tumor cells comprising a HER2 mutation. Conversely, the patient does not respond to T-DM1 treatment if the tumor cells contain a HER2 mutation but no specific protein fragment is detected. Detection of HER3 in tumor cells is a positive predictor of response to treatment. |
| priorityDate |
2017-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |