| abstract |
The present invention relates to a composition for inhibiting sodium leak channel (NALCN) comprising N-Benzhydryl Quinuclidine (NBQN) or derivatives thereof, wherein NBQN or its derivatives inhibit NALCN to excite cells It can control the excitation of the cells by stimulation bar, can be used in various aspects, such as medicinal, quasi-drug, cosmetic, cosmetic composition for the prevention or treatment of various diseases caused by NALCN or more It is expected to be. In addition, the NBQN or its derivatives of the present invention specifically inhibit NALCN only and do not affect other membrane ion channels. Therefore, it is expected that the NBQN or its derivatives will be usefully used for the study of the function, function, and mechanism of NALCN. |