| abstract |
A first TAA in physical connection with a tumor cell-derived substance (TCDM) comprising at least one innate stimulatory receptor (ISR) -binding construct that binds to an ISR expressed on an antigen-presenting cell (APC), and at least one other TAA Provided herein are tumor-associated antigen (TAA) presenting construct constructs comprising at least one TAA-binding construct that is directly bound to. The ISR-binding construct and the TAA-binding construct are linked to each other and the TAA presenting construct construct elicits a multiclonal T cell response against the first TAA and one or more other TAAs. Also provided are methods of using the TAA presentation inducer constructs, for example in the treatment of cancer. |