http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190129703-A

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filingDate 2019-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06f07cdf37f4cc7f70803882c16e9df7
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publicationDate 2019-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20190129703-A
titleOfInvention Screening system for inhibitors of astrocyte-specific passive conductance and its application
abstract The present invention relates to a composition capable of regulating astrocyte specific passive conductivity, and further relates to a system for screening a glial specific passive conductivity inhibitor using the drug, and the use thereof. By using the spagine (Spadin) passive conduction inhibitory effect of the spade according to the present invention, it can be used as a passive conduction inhibitor search system, using astrocytes that inhibit the gene expression of TREK-1 or TWIK-1 ion channel Therefore, it is possible to develop a screening system for the discovery of substances that control TWIK-1 / TREK-1 heterozygous-dependent and non-dependent passive conduction, and to contribute to the study of related physiological phenomena, pathogenesis of diseases and the development of therapies. .
priorityDate 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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