| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee496f20bb0f8d60f234cb4671fafe64 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5161
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0093
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1244
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc4b29f38a37c5f62e640a0ac43ed801
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0930ecbec2e51d5f588fff21597736e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_556cc5c9010899d4503ce739306dccb8 |
| publicationDate |
2019-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20190121613-A |
| titleOfInvention |
copolymer of polyethyleneimine-grafted chitosan with RGD dendrimer peptide for targeting integrin αvβ₃and the nanoparticles for gene delivery the same |
| abstract |
The present invention is a copolymer of polyethyleneimine grafted chitosan having RGD dendrimer peptide for integrin αvβ₃ targeting (RPgWSC) and nanoparticles comprising the same, and a copolymer of polyethyleneimine grafted chitosan having RGD dendrimer peptide for integrin αvβ₃ targeting. The present invention relates to a composition for anticancer, wherein the RPgWSC copolymer according to the present invention can deliver genes to cells through microtubule-dependent macropinocytosis and chitosan-mediated endocytosis. In addition, injection of the RPgWSC copolymer into a mouse model bearing PC3 tumor xenografts significantly inhibited tumor growth due to inhibition of BCL2 protein expression. Based on these results, RPgWSC copolymers are expected to be good candidates for specific target gene carriers that are not cytotoxic. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114099699-A |
| priorityDate |
2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |