| abstract |
The present disclosure relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising a cereblon E3 ligase binding compound, which are degraded and / or degraded by modulators of targeted ubiquitination, in particular bifunctional compounds according to the invention. Or find utility as inhibitors of various polypeptides and other proteins that are otherwise inhibited. In particular, the present disclosure provides a compound containing a ligand that binds to a cereblon E3 ubiquitin ligase on one end and a residue that binds to a target protein on the other end, the target protein being in proximity of the ubiquitin ligase. Position and affect the degradation (and inhibition) of the protein. Compounds can be synthesized to exhibit a broad range of pharmaceutical activities consistent with the degradation / inhibition of almost any type of targeted polypeptide. |