| abstract |
The present invention relates to a gastroretentive controlled release formulation comprising two or more sections and a method for producing the gastroretentive controlled release formulation comprising: a first compartment containing a pharmacologically active ingredient; And a second compartment comprising an air layer, wherein the first compartment comprises a release channel of the pharmacologically active ingredient. The present invention includes one or more compartments comprising an air layer, thereby continually releasing the drug while staying in the stomach for a long time. Accordingly, in the case of drugs whose absorption is limited to the upper gastrointestinal tract, the bioavailability of the drug is increased, and the pharmacokinetic properties and therapeutic efficacy of the drug targeted to the gastrointestinal tract are improved. |