http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190107887-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2276405ae0e23cfcd15651de21c8565 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2013 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 2018-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9c9dbd8dc2359dda29d7d2f2f290d28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f45a9df340b719701cada467de60f15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a630b8332e8889e18bed8cfa5335fd7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49ed93490288a76d99571edb4965e7ec |
| publicationDate | 2019-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20190107887-A |
| titleOfInvention | Solubilization formulation comprising apixaban and preparation method for the same |
| abstract | The present invention relates to a pharmaceutical formulation which improves the dissolution rate and bioavailability of poorly soluble Apixaban. In particular, the present invention relates to a pharmaceutical preparation prepared by a method comprising the steps of mixing Apixaban and a water-soluble polymer, and wet-wetting and vacuum drying. The formulation of the present invention not only improves the dissolution rate and bioavailability of poorly soluble Apixaban, but also has an excellent effect of reducing cost and reducing side effects by reducing the content of Apixaban in the formulation by 25% or more, preferably 50% or more. . In addition, the manufacturing method of the present invention improves the safety problems due to the organic solvent by the simultaneous wet and drying process. |
| priorityDate | 2018-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.