| abstract |
The present invention relates to organic compounds which inhibit cellular protection, in particular cardiac and kidney protective organic compounds, preferably substrate phosphorylation by G protein binding receptor kinase 2 (GRK2, ADRBK1). Preferably, the organic compound is a serine / arginine rich splicing for treating hypertension, heart disease, cardiac dysfunction or failure and heart disease related conditions such as cardiomyocyte necrosis, ischemic heart disease and / or ischemic heart damage or aging Inhibits GRK2 mediated phosphorylation of factor 1 (SRSF1, ASF-1, SF2) and / or phosducin. The present invention also relates to a method for identifying (SRSF1) and / or (GRK2) mediated phosphorylation inhibitors of phosducin. |