http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190101963-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee602c630e57f59c6cfc1c1634e36064 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2017-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a943f0c4c87d8f0260e5fcac27e6e9fa |
| publicationDate | 2019-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20190101963-A |
| titleOfInvention | Fast-acting insulin analogs that enhance stability |
| abstract | Two-chain insulin analogues include modified A-chain polypeptides and modified B-chain polypeptides. The modified A-chain polypeptide may comprise a His or Glu substituent at the A8 position; Glu substituent at the A14 position; And one or more Gln or Arg substituents at the A17 position. The modified B-chain polypeptide may be selected from the group consisting of a deletion of amino acids at the B1, B1-B2, B1-B3, B30, or a combination thereof; Ala or Glu substituent at the B2 position; And one or more Glu substituents at the B3 position. The analogs show thermodynamic stability, reduced magnetic binding, maintenance of biological potency, and increased mitosis in zinc-free solutions. The analogs show resistance to chemical and physical degradation. A method for treating a diabetic or obese patient includes administering to a patient a physiologically effective amount of an insulin analog or a physiologically acceptable salt thereof. |
| priorityDate | 2016-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 358.