| abstract |
Anti-human 4-1BB antibodies and fragments thereof are provided that have one or more structural features not found in the reference anti-human 4-1BB antibody, wherein the features can improve certain characteristics of the antibody as compared to the reference antibody. Various in vitro and in vivo methods and reagents associated with the anti-human 4-1BB antibodies described herein are also provided. The methods include, for example, inducing T-cell proliferation using anti-human 4-1BB antibodies or fragments thereof, inducing T cell secretion of IFNγ, as well as detecting, preventing and / or treating cancer. It includes ever healing. |