| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f7943e1a1abf9c1fe0154d63f82fbd0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L5-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K5-101 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L5-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08K5-101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-20 |
| filingDate |
2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d98eefad7db4fbcd4f82b6f8092f73c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34cb20db0ecef7230ebd3204233e2716
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbc8e36a24fc20e5068486145adec065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6e8e185595305a905e2ee94b0a4e4b3 |
| publicationDate |
2019-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20190092202-A |
| titleOfInvention |
Cell-instructed delivery system using tuning the toughness of an alginate microgel |
| abstract |
The present invention relates to a cell-driven delivery system through the control of the mechanical properties of the alginate microgel, according to the present invention, a microgel cross-linked with calcium ions by introducing methacrylate to the alginate molecule and mixed with the pure alginate molecule, and polyethylene The addition of glycol diacrylate and the addition of chemical crosslinking together with the ionic crosslinking can produce microgels having various strengths and toughness through grafting of methacrylate and control of chemical crosslinking. Prepared by ion crosslinking, the microgel system has a toughness (W T ) of 213 J / m 2 and a compressive strength (E) of 7.5 kPa to ensure that the neurons break up and release the gel after proliferation and differentiation. In addition, the cell-driven delivery system of the present invention systematically regulates the mechanical properties of the gel according to the cell towing and can control the release according to the degree of differentiation of the gel. Can be utilized. |
| priorityDate |
2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |