| abstract |
An object of the present invention is a chemically modified siRNA in which polydeoxyadenylic acid is added to the 5 'end of a sense chain. When complexed with sizopyran, the chemically modified siRNA has high resistance to RNase and exhibits RNAi activity effectively. to provide an siRNA. In a modified siRNA in which polydeoxyadenylic acid is added to the 5 'end of the sense chain, the dinucleotide sequence of CA, UA and UG in the base sequence of the sense chain, and the 8th from the 5' end side of the antisense chain. The said subject can be solved by giving specific chemical modification about the dinucleotide sequence of CA, UA, and UG in the following nucleotide sequence. |