| abstract |
The present invention relates to a pharmaceutical composition for the prophylaxis or treatment of immunological diseases and inflammatory diseases including stem cells or cultures thereof cultured by adding an agonist of NOD2 to stem cells expressing NOD2, A composition, a method for inhibiting an immune response or an inflammatory reaction of a subject comprising the step of administering the stem cell or a culture thereof to a subject, a method for producing an immunosuppressant or an anti-inflammatory agent using the stem cell or a culture thereof , A step of culturing stem cells expressing NOD2 by adding an agonist of NOD2 to PGE 2 Or TGF-? 1, a stem cell expressing NOD2 and an implant comprising an agonist of NOD2, a method of producing the graft, a complex comprising a stem cell expressing NOD2 and an agonist of NOD2, and NOD2 The present invention relates to a culture obtained by adding an agonist of NOD2 to an expressing stem cell. The pharmaceutical composition according to the present invention can be used as a cell therapy agent which can be used economically and without side effects, replacing existing immunosuppressive agents and inflammation inhibitors known to have side effects, and is useful as an immunological diseases and infections such as autoimmune diseases such as clonus disease, rheumatoid arthritis, Which can be used for the prevention or treatment of inflammatory diseases. |