| abstract |
Disclosed herein are functionalized biocompatible nanoparticles capable of intracellular delivery of a plurality of biologically active molecules for modulating cell function and penetrating mammalian cell membranes. The functionalized biocompatible nanoparticles comprise: a central nanoparticle having a size range of from about 5 to about 50 nm, the central nanoparticle having a polymer coating thereon, a plurality of functional groups covalently attached to the polymeric coating, A plurality of biologically active molecules are attached to a plurality of functional groups, a plurality of biologically active molecules include one or more peptides and proteins, peptides can penetrate into a cell through a mammalian cell membrane, And a plurality of functional groups. The protein may be a transcription factor selected from the group consisting of Oct4, Sox2, Nanog, Lin28, cMyc, and Klf4. |