| abstract |
An antibody drug conjugate (ADC) comprising an antibody that binds to the glycosylated antigen disclosed herein or conjugated to an antigen-binding fragment thereof, as well as methods of use thereof. Methods of use include, but are not limited to, cancer therapy and diagnostic methods. An antibody of the disclosure can bind to a specific cancer cell surface. Exemplary targets of antibodies disclosed herein include, but are not limited to, carcinomas such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioma, lung cancer, breast cancer, oral cancer, head and neck cancer, nasopharyngeal cancer, esophageal cancer, gastric cancer, liver cancer, cholangiocarcinoma, , Colorectal cancer, colorectal cancer, renal cancer, cervical cancer, endometrial cancer, ovarian cancer, testicular cancer, narrow-gauge cancer, canine cancer, laryngeal cancer and prostate cancer. |