| abstract |
The present invention provides a pharmaceutical composition comprising two or more compounds wherein each compound is independently selected from the group consisting of a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H 1 -receptor agonist, a histamine H 2 -receptor A histamine H 3 -receptor antagonist, or a β 2 -adrenoceptor agonist. The present disclosure also provides a method of treating, preventing, or ameliorating a cardiovascular disease in a subject comprising administering two or more compounds to a subject in need thereof, wherein each compound is an independent Receptor antagonist, calcium channel blocker, histamine H 1 -receptor agonist, histamine H 2 -receptor agonist, histamine H 3 -receptor antagonist, or β 2 -adrenoceptor agonist. |