| abstract |
The present invention discloses a nitrogen-containing macroreticular compound, a method for producing the same, a drug composition and a use thereof. The present invention provides a nitrogen-containing macroreticular compound represented by the formula III-0, a tautomer thereof, an optical isomer thereof, a hydrate thereof, a solvate thereof, a pharmaceutically acceptable salt thereof or a prodrug thereof. By effectively binding to the Bromine domains of the compound BET family BRD4, BRD3, BRD2, and BRDT to regulate the transcription of the downstream gene c-myc and the target gene associated therewith, the downstream signal pathway is controlled to exert its specific action, Diseases, cancers, and AIDS. |