abstract |
Disclosed are compounds of formula (I) wherein R, R 1 , R 2 , R 3 , Y, Y 1 , a, X and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and may be useful in the treatment of duodenal muscular dystrophy. Accordingly, the present invention further relates to a pharmaceutical composition comprising a compound of the invention. The invention further relates to methods of inhibiting H-PGDS activity and methods of treating disorders associated therewith using a pharmaceutical composition comprising a compound of the invention or a compound of the invention. |