| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ba7ff2ceeaa38b91652a71dad8539a8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2017-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f519f9e8f41581cc998b271330321be1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fde3c132344d169ef9058b10712491d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30347814ea389b819098c71e29c9ad0e |
| publicationDate |
2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20190072559-A |
| titleOfInvention |
Rationally-designed synthetic peptide shuttles for delivery of a polypeptide cargo from the extracellular space to the cytoplasm and / or nucleus of the target eukaryotic cell, its use, methods and kits related thereto |
| abstract |
The present invention relates to a method for delivering a polypeptide cargo from the extracellular space to the cytoplasm and / or nucleus of a target eukaryotic cell. The method comprises contacting the cell with the polypeptide cargo in the presence of a peptide shuttling agent at a concentration sufficient to increase the efficiency of transduction of the polypeptide cargo. Also contemplated herein are variables that can be used in the rational design of such synthetic peptide shuttles, peptide shuttles that satisfy one or more of these design variables, as well as various polyfunctional molecules from the extracellular space of target eukaryotic cells to the cytoplasm and / Methods and compositions related to the use of synthetic peptide shuttles for the delivery of peptide cargo (e.g., transcription factors, antibodies, CRISPR-associated nuclease and functional genomic editing complexes) are described. Applications and targets for genomic-editing NK cells for improved immunotherapy are also described. |
| priorityDate |
2016-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |