| abstract |
The present invention relates to a silica nanoparticle for biomarker diagnosis and a method for preparing the same, and more particularly, to a silica nanoparticle for biomarker diagnosis which can measure a glycated protein such as glycated hemoglobin, saccharide albumin, And a manufacturing method thereof. The silica nanoparticles for biomarker diagnosis, in which the reactive polymer and the non-reactive polymer according to the present invention are immobilized on the surface and the dye is immobilized therein, can be prepared by immobilizing a dye in a covalent bond within the silica nanoparticle, It is advantageous that the dye is not influenced by the environment and the stability is improved even when the organ is stored. In addition, by fixing several dye molecules in one silica nano particle, the amount of light absorbed by one particle is equal to the absorption amount of one dye molecule It is possible to accurately measure the amount of glycated protein that is amplified and has a lower detection limit. In addition, since the reactive polymer, in which the non-reactive polymer and the probe are combined, is immobilized on the surface of the silica nanoparticle immobilized with dye on the inside thereof, the influence of various proteins and salts included in the sample is minimized, It can be applied to a point-of-care testing system using a biological sample, and can be utilized for quickly and accurately measuring a biological indicator aiming at detection in a stable manner. |