http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190067260-A

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filingDate 2012-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c3240ed9840ec2f38603ca7f801efcb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c326c174804fdd535f18fb15038a89b3
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publicationDate 2019-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20190067260-A
titleOfInvention L-Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
abstract The present invention relates to (a)nA first step of providing a comparative nucleic acid molecule, wherein the comparative nucleic acid molecule is capable of binding a target molecule and the comparative nucleic acid molecule comprises a nucleotide sequence comprising n nucleotides; (b)nA second step of preparing a first class derivative of the nucleic acid for comparison wherein the first class derivative of the nucleic acid molecule for comparison is different in one nucleotide position from the comparative nucleic acid molecule, Deoxyribonucleotide at said one nucleotide position, and wherein said comparative nucleic acid is substituted at the nucleotide position with a deoxyribonucleotide at said nucleotide position, and wherein said comparative nucleic acid has a ribonucleotide at said nucleotide position, In the case of having a ribonucleotide, the deoxyribonucleotide is prepared by substituting the ribonucleotide at the one nucleotide position, and the nucleotide position at which the substitution is made is the modified nucleotide position); And (c)nRepeating the step (b) at the position of the individual nucleotide of the comparative nucleic acid molecule to produce a first derivative group of the nucleic acid for comparison, wherein the first derivative group of the comparative nucleic acid molecule comprises n Wherein each of the first derivative groups of the nucleic acid molecule for comparison is different from a comparable nucleic acid molecule by a single nucleotide substitution and each of the first class derivatives of the nucleic acid molecule for comparison comprises , Wherein one modified nucleotide among all single-modified nucleotide positions of the other first derivatives of the first derivative group of the comparative nucleic acid molecule has a single modified nucleotide position) To a process for producing a nucleic acid molecule capable of binding.
priorityDate 2011-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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