| abstract |
Compositions and methods for producing an improved effective immune response against an immunogen in humans are described. Increased immune responses are obtained by using adenoviral vectors as MVA vectors and boosts as primers, and are characterized by high levels of antibody response specific for immunogen, and an enhanced cellular immune response. The compositions and methods can be used to provide protective immunity against diseases such as infection of one or more subtypes of Ebola and Marburg Pirovirus in humans. |