| abstract |
The present invention discloses a method of treating a subject's proliferative disease by administering a DNA-damaging agent to a subject and administering a DNA-PK inhibitor to the subject after about 8 hours to about 48 hours. Exemplary DNA-PK inhibitors are represented by the formula BI or a pharmaceutically acceptable salt thereof. The formula (BI) In the above formula (BI), R 1 , Q, ring A, and ring B are defined herein. |