| abstract |
The present invention provides compositions and methods for delivering a therapeutic agent across a barrier. Such compositions include therapeutic agents (e.g., antimicrobial agents, antibiotics, or anesthetics), penetration enhancers that increase the flux of the therapeutic agent across the barrier, and matrix formers. The matrix former forms a gel at a suitable gelation temperature, has rheological properties for use in drug delivery, and in some cases such gelation temperature and rheological properties are not significantly altered from the properties of the composition without the penetration enhancer Do not. The present invention also provides matrix formers and compositions thereof. Such compositions are particularly useful for the treatment of infectious diseases (e. G., Otitis media). Methods for treatment, delivery methods, and kits for the compositions described herein are also provided. |