| abstract |
The present invention relates to a recombinant herpesvirus which comprises a GCN4 yeast transcription factor fused or inserted into a glycoprotein H or a part thereof and is capable of binding to a target molecule present on a cell for the proliferation and production of a herpes virus. Herpes viruses may include further modifications in glycoprotein D and / or glycoprotein B for retargeting herpes viruses into disease cells. The invention also relates to nucleic acid and vector coding for gH, polypeptides comprising gH, and cells comprising a herpes virus, nucleic acid, vector or polypeptide. The present invention also relates to a cell having a target molecule on a surface accessible GCN4 yeast transcription factor or part thereof and to a method of producing the herpes virus in said cell. |