| abstract |
The present invention provides compositions and methods for the use of oxytocin antagonists, such as substituted pyrrolidin-3-one oxime derivatives, among other compounds in the treatment of subjects undergoing embryo transfer therapy. The compositions and methods of the present invention improve, for example, after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) embryo transfer procedures. In order to improve endometrial receptivity and reduce the likelihood of embryo implantation failure and abortion, (3 Z, 5 S) -5- ( hydroxymethyl) -1 - [(2'-methyl-1,1'-biphenyl-4-yl) carbonyl] pyrrolidin-3-one O-methyl Oxytocin antagonists including oximes can be used to administer to a subject. |