http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190038921-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-065 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34 |
| filingDate | 2017-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f10dbbebfb8dc3bd1f7d73aa1b89c3fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2de0905221565e24f09601771b04544c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c8fdf37c685f606592472facd637848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c382f13fb6e0a79daaab3047d943c565 |
| publicationDate | 2019-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20190038921-A |
| titleOfInvention | Method for producing highly concentrated liquid formulation containing biomolecules |
| abstract | (a) first ultrafiltration UF1 step; (b) a first filtration step DF1; (c) second filtration step DF2; And (d) a second ultrafiltration UF2 step, wherein an aqueous solution of one or more salts as liquid medium B is used in step (b) and an aqueous solution or water of at least one salt as liquid medium C is added to step (c) Wherein the at least one salt used in step (b) is the same or different than the one or more salts used in step (c), and wherein the liquid medium B has an ionic strength that is higher than the ionic strength of the liquid medium C An improved multistage preparation method of a highly concentrated liquid formulation containing biomolecules is disclosed. The process according to the invention makes it possible to prepare well-defined, highly concentrated formulations containing biomolecules, in particular proteins, intended for pharmaceutical or non-pharmaceutical uses. The undesirable excipient (s) of the starting liquid biomolecule formulation can be reduced to a very low level or a level below the detection limit under solution conditions. |
| priorityDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1483.