| abstract |
[PROBLEMS] To provide a medicament for preventing or treating Parkinson's disease, which has little or no side effects and is effective. Means for Solving the Problem: The present inventors have found that thioredoxin 1 can be fused together with a protein transport domain to enable penetration into cells or tissues, so that the thioredoxin 1 fusion protein can induce both MPP + and MPTP-induced dopaminergic cell death, And whether the cells express the cytoprotective effect in the disease model. As a result, it was confirmed that the cell permeable thioredoxin 1 fusion protein has potential as an effective protein therapeutic agent in Parkinson's disease. |