| abstract |
The present disclosure provides a method for isolating structural information at the genomic or chromosomal level from a preserved sample. In some cases, a sample, such as a FFPE sample, stored under conditions where long range nucleic acid information is considered to be unrecoverably lost, is treated to recover the stabilized nucleic acid-protein complex as part of the sample preservation process. The complex is processed to recover information as to which nucleic acid is bound to a common complex, and the information is used to recover structural information of the genome. |