| abstract |
The Cxcl12 deficient mice of the present invention are useful in the treatment of abnormal T / D development, placenta formation, aortic arch patterning, pulmonary artery patterning, cardiac development, intersegmental artery patterning, craniofacial area) and exhibits abnormal vascular developmental symptoms as well as clinical signs of BPS. Thus, Cxcl12 knockout mice can be used not only in research on the cause of the invention of pulmonary sequestration but also in the development and validation of therapeutic methods Can be used as a useful animal model. |