| abstract |
The present invention provides an injectable composition for delayed drug delivery and a method of preparing the same, wherein the composition has a weight average molecular weight between 5,000 daltons and 50,000 daltons, an acid value less than 3 mg KOH / g, and less than about 0.3% lactate polymer A lactate-based polymer having a content of residual lactide monomer in the polymer; A pharmaceutically acceptable organic solvent; And a physiologically active substance or salt thereof containing amino acid serine in a molecular structure capable of forming a conjugate by reacting with a lactide monomer; The composition reduces the formation of a conjugate. |