http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190029355-A

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filingDate 2017-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20190029355-A
titleOfInvention Once a day oral dosage sustained-release formulation comprising itopride
abstract The sustained-release sustained-release double-layered tablets containing the itopride hydrochloride of the present invention can be used as an immediate release layer for rapidly eluting the drug and a slow release layer for gradual release in order to simultaneously satisfy rapid pharmacological activity development and sustained pharmacological activity for 24 hours Hydroxypropylmethylcellulose having a specific degree of substitution and viscosity according to a specific degree of substitution and viscosity is used as a release controlling agent and a dissolution rate in each portion of the gastrointestinal tract having different pH And the residence time in the gastrointestinal tract. The present invention also provides a method for preparing an itopride hydrochloride-containing sustained-release sustained-release biodegradable tablet, which is designed to prevent adverse effects due to excessive release of the initial effective ingredient while maintaining compliance with the patient's medication and maintain a uniform dissolution rate.
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