abstract |
The present invention relates to codon-optimized IL-21 and uses thereof. According to the present invention, when a selected signal peptide is linked as a secretory leader sequence to enhance secretion efficiency in codon-optimized IL-21 so that IL-21 is highly expressed and secreted in CHO cells, which are mammalian cells, As a production host, it was confirmed that the production yield of IL-21 in the CHO cell line was improved and overcome the biological function problem that occurred when the prokaryote was used as a host, which can be usefully used for mass production of high quality IL-21 . |