| abstract |
The present invention provides a method for improving skin retention of a compound effective for prevention or improvement of skin aging. The skin external preparation for oil gel of the present invention comprising 1) a compound represented by the following formula (1), an isomer thereof and / or a pharmacologically acceptable salt thereof and 2) a partially crosslinked methylpolysiloxane, 1) easily migrates to the skin, enhances the skin absorbency, and improves the retention of the skin. Wherein R 1 represents a straight or branched alkyl group having 1 to 4 carbon atoms substituted with a carboxyl group or a linear or branched alkyl group having 1 to 4 carbon atoms substituted with a carboxylate group having an alkyl chain having 1 to 4 carbon atoms, And R 2 and R 3 each independently represent a linear or branched alkyl group having 1 to 4 carbon atoms. |