| abstract |
The present invention relates to N- (substituted-phenyl) -sulfonamide compounds which are very useful as inhibitors of protein kinases (e. G., PERK kinase) and are useful for the treatment of cell proliferative disorders such as cancer, Can be used for the treatment of diseases associated with the activated unfolded protein response pathway. The present invention also provides methods for the manufacture of these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases using pharmaceutical compositions comprising these compounds. |