| abstract |
Anti-CD47 monoclonal antibodies and uses thereof. The anti-CD47 monoclonal antibody provided by the present invention can effectively inhibit tumor growth and can block the human SIRP and human CD47 signal to promote phagocytosis of macrophages to tumor cells, The anti-tumor effect can be exerted by preventing the defensive system of the animal. By blocking the binding of CD47 on the surface of tumor cells to SIRP on the surface of macrophages, it can block the "do not eat me" signal of tumor cells and promote the recognition and ingestion of macrophages into tumor cells, Can be promoted. The combination of CD47 on the tumor cell surface with SIRP on the macrophage surface is a universal "do not eat me" signal, and the anti-CD47 antibody is a very promising target in the tumor immune system as a powerful and effective Action can be exerted. |