| abstract |
The present invention relates to a multi-arm, drug conjugate having a structure represented by Structural Formula (III), which is a target drug conjugate modified with a water-soluble polymer. (Wherein R is an organic center, POLY is a polymer, L is a multivalent linker, T is a target molecule, D is a camptothecin drug, and q is an arbitrary integer of 3 to 8) The drug conjugate can improve the poor water solubility, high toxicity, and low bioavailability of the camptothecin drug. |