| abstract |
Suitable aqueous compositions for topical administration to the human or animal body include, together with a water-soluble analgesic, at least one water-soluble polymeric lens and a lubricant, for example, hyaluronate, carbomer gel or hiromellose. The analgesic may be an opioid, in particular an opioid with affinity for the 5-HT receptor, for example tramadol. Typical tramadol levels will be in the range of 0.5% to 1.0% w / v. These aqueous compositions can be used, for example, as artificial tears and as a general ophthalmic lubricant for the treatment of diseases such as ocular drying or eye irritation. Additional compositions combine an ophthalmologically-active agent, e. G., A medicament, with an opioid, e. G. In particular tramadol. These compositions can be used to treat the eye, reduce the pain or discomfort typically experienced by administering these particular drugs to the eye, and to increase the efficacy of the medicament. Compositions containing opioids with 5-HT receptor activity, which are commonly used to alleviate pain in or around the eye, are also disclosed. |