| abstract |
The present invention discloses a composition for improving skin wrinkles or skin moisturizing using a dried extract of P. mandarin. In the nonclinical efficacy test using an experimental animal irradiated with UVB, the extract of the plant extract suppressed the formation of wrinkles and water loss due to photoaging and inhibited skin inflammatory factors (IL-1β, IL-6, TNF-α, NOS-2 and COX-2 ) And inhibit the expression of collagenase MMP-2 and MMP-9, as well as inhibit the increase of epithelial thickness and increase collagen content, and are applied to 21 human subjects over 30 years old The test also shows the effect of improving the wrinkles of the skin. |